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KMID : 0358520100220040371
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Korean Journal of Occupational and Environmental Medicine
2010 Volume.22 No. 4 p.371 ~ p.377
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The Brain Pathology on Recovery of Brain MRI after Manganese Administration in Rats
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Jung Ji-Hyeon
Kim Jung-Il
Kim Se-Young
Jung Min-Ho
Choi Sun-Seob
Kim Soo-Jin
Park Young-Jin
Jung Kap-Yeol
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Abstract
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Objectives: This study was carried out to investigate the effect on manganese on the brain of Sprague-Dawley rats, with particular focus on changes to anatomical pathology when brain MRI was recovered after manganese administration.
Methods: There were 15 rats divided into 3 groups of 5 based on dose of manganese: control group, low dose group (10 ㎎/㎏), and high dose group (40 ㎎/㎏). Each dosing group received an injection of normal saline and manganese via the tail vein once a week for 4 weeks. And then, the rats were observed for 12 weeks after stopping manganese administration. Next, each rat underwent a brain MRI and then each was sacrificed. After the rats were killed, the concentrations of blood manganese were measured, and pathologic examinations of the brain were performed.
Results: The signal intensity of basal ganglia on T1-weighted imaging of brain MRI did not differ between dosing groups. However, the ratio of neuron/glial cell in the basal ganglia was decreased in the low- and high-dose groups compared to the control group.
Conclusions: This study showed that the damage of neuron in basal ganglia might be permanent after signal intensity of basal ganglia on T1-weighted imaging of brain MRI was recovered.
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KEYWORD
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Manganese, Brain, MRI, Pathology
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